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NEUROX™

NEUROX™

$49.99

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Highlights

  • Heightens Cognitive Clarity
  • Enhances Energy, Mood, and Focus
  • Improves Mind-Muscle Connection
  • Promotes Better Concentration
  • Amazing Taste
  • Clinical Dosing & Fully Transparent Labels
Description

NeuroX™ is Purge Supps latest, high-energy formula. This nootropic + stim product is built for improving every aspect of neurological function.

  • Lion’s Mane Improves Cognition
  • Rhodiola Rosea Provides Adaptogenic Neuroprotection
  • Kanna Ease™ Helps Control Anxiety
  • The Caffeine Complex Boosts Energy and Wakefulness
  • L-Theanine Takes the Edge Off

If you’ve ever used a pre-workout for anything other than a great workout, NeuroX™ is for you!

Ingredient Profile

Lion’s Mane

A special type of mushroom containing active components Hericenones, Erinacines, and antioxidants.

  • Improves neuron health by reducing overstimulation, promoting regeneration, and limiting stress.
  • Has antioxidant effects
  • Helps with managing lipids and metabolism

 

L-Tyrosine

L-Tyrosine helps to activate metabolic pathways that adrenaline – which are typically produced during acute stress and “fight or flight” scenarios.

  • Adrenaline is quickly depleted during stressful moments due to a lack of L-Tyrosine.
  • Supplements including L-tyrosine and caffeine can maintain reaction time and improve subjective feelings of focus and alertness following exhaustive exercise.
  • Structurally similar to thyroid hormones and may help in their formation.

Choline Bitartrate

Choline is an essential nutrient for brain health and synaptic plasticity.

  • Choline improves structural integrity, signaling capacity and the fluidity of neural membranes. It’s estimated that close to 90% of the population does not get the recommended amount of choline daily.
  • It has been shown that a dose of 500mg of Choline can boost focus, mood and concentration abilities.
  • This is tantamount to pushing through your workout. Utilizing this effectively dosed compound, you will be able to focus on taking less rest or being distracted during your training. Giving your 110% will really be your 110%.
  • A study conducted by Sun et al. (1999) reported that subjects who supplemented with choline for 4 weeks improved learning performance and memory compared to a placebo group.

 

Mucuna Pruriens

Mucuna seed is a rich source of L-DOPA which mimics dopamine in the body.

  • Mucuna supplementation has been shown to decrease cortisol levels

 

Rhodiola Rosea

Rhodiola Rosea root extract has a wide range of adaptogenic functions, which means it may help you deal with stress and manage its effect on your body.

  • One way that Rhodiola may help is by supporting the neurological mechanisms that deal with stress.
  • It may also reduce fatigue and exhaustion in prolonged stressful situations.
  • Research suggests Rhodiola can have a positive effect on cognition, feelings of well-being, and decrease symptoms of depression.
  • A study conducted by Edwards et al. (2012) found Rhodiola extract used twice daily for 4 weeks in persons with life and work-related stress was able to greatly reduce dysfunction and fatigue associated with stress in a time-dependent manner.

 

Dimethylethanolamine

Dimethylethanolamine, or DMAE, is an antioxidant and cognitive support ingredient.

  • Helps protect from iron-induced oxidation to provide anti-oxidative effects and maintain cell membrane integrity.
  • May be able to improve skin health by decreasing spots and improving elasticity

 

Kanna Ease

Kanna is a psychoactive herb without hallucinogenic or habit-forming properties. It is traditionally used prior to stressful events to curb anxiety and improve performance.

  • Inhibits phosphodiesterase 4 in the amygdala to exert antidepressive effects.
  • Has been noted to have powerful reductions in anxiety
  • Improves cognition and executive functioning during tests

Caffeine Anhydrous

Caffeine is the world’s most popular supplement. It is capable of many things, including increasing metabolic rate and thermogenesis, boosting fat oxidation, enhancing pain tolerance, and improving athletic performance.

  • One study in trained athletes found improved power output (7%) and total work performed (8.5%) compared to placebo. More power and more work equals more gains.
  • Supplementation with 400mg caffeine (the amount in RIPTX) has been found to increase thermogenesis by 300 Calories per day – potentially eliminating an entire day’s worth of calories over a 1 week span.
  • Can improve endurance performance up to 40%.

 

Infinergy™ Dicaffeine Malate

Infinergy™ provides all of the same great benefits as caffeine anhydrous. However, it’s specialized form with malic acid affords it the benefit of having no crash or jitters.

  • Adrenaline, fat oxidation, performance, no crash!

 

Green Tea Extract

Green Tea Extract is an herbal derivative from green tea leaves, containing antioxidant ingredients and thermogenic compounds.

  • This extract contains high amounts of catechins, including EGCG which helps with the metabolism of fat at rest and during exercise performance.
  • Green tea also reduces the formation of free radicals in the body which protect cells and molecules from damage.
  • A meta-analysis of 11 studies looking at green tea consumption over a period of 12 weeks’ minimum noted, on average, 1.31kg weight loss.

 

Dynamine

Dynamine is methylliberine – an alkaloid isolated from kucha tea. It is similar to TeaCrine, but it works faster and provides a more intense effect.

  • Reported to work in as few as 10 minutes.
  • May improve mood, focus, and energy levels.
  • One of the actives alkaloids in coffee.


    L-Theanine

    L-Theanine is an amino acid, that when consumed produces GABA, a neurotransmitter which acts on the brain to reduce the perceived stress.

    • Research suggests that L-Theanine’s biggest supplemental role may be in taking the “edge” off of other stimulants.
    • A combination of L-Theanine with caffeine is noted to be synergistic in promoting thermogenesis, cognition, and attention.
    • Giesbrecht et al. found the combination of L-theanine and caffeine significantly improved accuracy during task switching, self-reported alertness, and reduced self-reported tiredness.

      

    Rauwolfia Vomitoria

    Rauwolfia Vomitoria is a plant found in Africa that has been used in traditional medicine for heart, cancer, and brain ailments.

    • May reduce blood pressure and blood sugar.
    • Has been noted to reduce psychosis
    • Possibly effective for fat oxidation and attention by virtue of containing yohimbine.
    FAQs

    Q: What is the best way to use NeuroX™?

    A: As a dietary supplement, mix 1 scoop (5.5 grams) in 8-16oz of water and consume 20-30 minutes before exercise, work, or studying. Begin with a half (1/2) scoop to assess tolerance.

     

     

    References

    Lion’s Mane

    1. Wong, K. H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011). Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers.(Aphyllophoromycetideae). Evidence-based complementary and alternative medicine2011.
    2. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double‐blind placebo‐controlled clinical trial. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives23(3), 367-372.
    3. Kolotushkina, E. V., Moldavan, M. G., Voronin, K. Y., & Skibo, G. G. (2003). The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh49(1), 38-45.
    4. Ueda, K., Tsujimori, M., Kodani, S., Chiba, A., Kubo, M., Masuno, K., ... & Kawagishi, H. (2008). An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorganic & medicinal chemistry16(21), 9467-9470.
    5. Moldavan, M., Grygansky, A. P., Kolotushkina, O. V., Kirchhoff, B., Skibo, G. G., & Pedarzani, P. (2007). Neurotropic and trophic action of lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers.(Aphyllophoromycetideae) extracts on nerve cells in vitro. International Journal of Medicinal Mushrooms9(1).

    L-Tyrosine

    1. Benedict, C. R., Anderson, G. H., & Sole, M. J. (1983). The influence of oral tyrosine and tryptophan feeding on plasma catecholamines in man. The American journal of clinical nutrition, 38(3), 429-435.
    2. Alonso, R., Gibson, C. J., Wurtman, R. J., Agharanya, J. C., & Prieto, L. (1982). Elevation of urinary catecholamines and their metabolites following tyrosine administration in humans. Biological Psychiatry, 17(7), 781-790.
    3. Agharanya, J. C., Alonso, R., & Wurtman, R. J. (1981). Changes in catecholamine excretion after short-term tyrosine ingestion in normally fed human subjects. The American journal of clinical nutrition, 34(1), 82-87.
    4. Acworth, I. N., During, M. J., & Wurtman, R. J. (1988). Tyrosine: effects on catecholamine release. Brain research bulletin, 21(3), 473-477.
    5. Neri, D. F., Wiegmann, D., Stanny, R. R., Shappell, S. A., McCardie, A., & McKay, D. L. (1995). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine.

     

    Choline Bitartrate

    1. Moreno, H., de Brugada, I., & Hall, G. (2013). Chronic dietary choline supplementation modulates attentional change in adult rats. Behavioural brain research, 243, 278-285.
    2. Blusztajn, J. K., & Mellott, T. J. (2013). Neuroprotective actions of perinatal choline nutrition. Clinical Chemistry and Laboratory Medicine, 51(3), 591-599.
    3. Krzysztof Blusztajn, J., & J Mellott, T. (2012). Choline nutrition programs brain development via DNA and histone methylation. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents), 12(2), 82-94.
    4. Biasi, E. (2011). The effects of dietary choline. Neuroscience bulletin, 27(5), 330-342

    Mucuna Pruriens

    1. Shukla, K. K., Mahdi, A. A., Ahmad, M. K., Jaiswar, S. P., Shankwar, S. N., & Tiwari, S. C. (2010). Mucuna pruriens reduces stress and improves the quality of semen in infertile men. Evidence-Based Complementary and Alternative Medicine, 7(1), 137-144.
    2. Natarajan, K., Narayanan, N., & Ravichandran, N. (2012). Review on “Mucuna”—The wonder plant. Int J Pharm Sci Rev Res, 17(1), 86-93.

    Rhodiola Rosea

    1. Hung, S. K., Perry, R., & Ernst, E. (2011). The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.Phytomedicine, 18(4), 235-244.
    2. Edwards, D., Heufelder, A., & Zimmermann, A. (2012). Therapeutic Effects and Safety of Rhodiola rosea Extract WS® 1375 in Subjects with Life‐stress Symptoms–Results of an Open‐label Study. Phytotherapy Research, 26(8), 1220-1225.
    3. Spasov, A. A., Wikman, G. K., Mandrikov, V. B., Mironova, I. A., & Neumoin, V. V. (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine, 7(2), 85-89.
    4. Shevtsov, V. A., Zholus, B. I., Shervarly, V. I., Vol'skij, V. B., Korovin, Y. P., Khristich, M. P., ... & Wikman, G. (2003). A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine, 10(2), 95-105.
    5. Darbinyan, V., Aslanyan, G., Amroyan, E., Gabrielyan, E., Malmström, C., & Panossian, A. (2007). Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nordic Journal of Psychiatry,61(5), 343-348.

    Dimethylethanolamine

    1. Nagy, I. Z., & Nagy, K. (1980). On the role of cross-linking of cellular proteins in aging. Mechanisms of ageing and development, 14(1-2), 245-251.
    2. Uhoda, I., Faska, N., Robert, C., Cauwenbergh, G., & Piérard, G. E. (2002). Split face study on the cutaneous tensile effect of 2‐dimethylaminoethanol (deanol) gel. Skin Research and Technology, 8(3), 164-167.
    3. Grossman, R. (2005). The role of dimethylaminoethanol in cosmetic dermatology. American journal of clinical dermatology, 6(1), 39-47.

    Kanna Ease

    1. Terburg, D., Syal, S., Rosenberger, L. A., Heany, S., Phillips, N., Gericke, N., ... & Van Honk, J. (2013). Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus. Neuropsychopharmacology, 38(13), 2708.
    2. Chiu, S., Gericke, N., Farina-Woodbury, M., Badmaev, V., Raheb, H., Terpstra, K., ... & Sanchez, V. (2014). Proof-of-concept randomized controlled study of cognition effects of the proprietary extract Sceletium tortuosum (Zembrin) targeting phosphodiesterase-4 in cognitively healthy subjects: implications for Alzheimer’s dementia. Evidence-Based Complementary and Alternative Medicine, 2014.
    3. Smith, C. (2011). The effects of Sceletium tortuosum in an in vivo model of psychological stress. Journal of ethnopharmacology, 133(1), 31-36.

    Caffeine Anhydrous

    1. Bellar, D., Kamimori, G. H., & Glickman, E. L. (2011). The effects of low-dose caffeine on perceived pain during a grip to exhaustion task. The Journal of Strength & Conditioning Research25(5), 1225-1228.
    2. Bell, D. G., & McLellan, T. M. (2002). Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers. Journal of Applied Physiology93(4), 1227-1234.
    3. Schneiker, K. T., Bishop, D., Dawson, B., & Hackett, L. P. (2006). Effects of caffeine on prolonged intermittent-sprint ability in team-sport athletes. Medicine and science in sports and exercise38(3), 578-585.
    4. Del Coso, J., Salinero, J. J., González-Millán, C., Abián-Vicén, J., & Pérez-González, B. (2012). Dose response effects of a caffeine-containing energy drink on muscle performance: a repeated measures design. Journal of the International Society of Sports Nutrition9(1), 21.
    5. Anderson, D. E., & Hickey, M. S. (1994). Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Medicine and science in sports and exercise26(4), 453-458.
    6. Norager, C. B., Jensen, M. B., Weimann, A., & Madsen, M. R. (2006). Metabolic effects of caffeine ingestion and physical work in 75‐year old citizens. A randomized, double‐blind, placebo‐controlled, cross‐over study. Clinical endocrinology65(2), 223-228.
    7. Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., & Madsen, J. (1990). Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition51(5), 759-767.

    Infinergy® (Dicaffeine Malate)

    1. Sommerfeld, A., & Witherly, S. (2014). S. Patent No. 8,642,095. Washington, DC: U.S. Patent and Trademark Office.

    Green Tea Extract

    1. Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures. Outlaw J, Wilborn C, Smith A, Urbina S, Hayward S. J Int Soc Sports Nutr. 2013 Apr 30;10(1):25.
    2. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Am J Clin Nutr. 1999 Dec;70(6):1040-5
    3. Neurochemical and behavioral effects of green tea (Camellia sinensis): a model study. Mirza B, Ikram H, Bilgrami S, Haleem DJ, Haleem MA. Pak J Pharm Sci. 2013 May;26(3):511-6.
    4. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Hodgson AB, Randell RK, Jeukendrup AE. Adv Nutr. 2013 Mar 1;4(2):129-40.
    5. Metabolic response to green tea extract during rest and moderate-intensity exercise. Hodgson AB, Randell RK, Boon N, Garczarek U, Mela DJ, Jeukendrup AE, Jacobs DM. J Nutr Biochem. 2013 Jan;24(1):325-34.

    Dynamine

    1. Petermann, J. B., & Baumann, T. W. (1983). Metabolic relations between methylxanthines and methyluric acids in Coffea L. Plant physiology, 73(4), 961-964.
    2. Zheng, X. Q., Ye, C. X., Kato, M., Crozier, A., & Ashihara, H. (2002). Theacrine (1, 3, 7, 9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha). Phytochemistry, 60(2), 129-134.

    Octopamine

    1. Visentin, V., Morin, N., Fontana, E., Prévot, D., Boucher, J., Castan, I., ... & Carpéné, C. (2001). Dual action of octopamine on glucose transport into adipocytes: inhibition via β3-adrenoceptor activation and stimulation via oxidation by amine oxidases. Journal of Pharmacology and Experimental Therapeutics, 299(1), 96-104.
    2. Flechtner-Mors, M., Jenkinson, C. P., Alt, A., Adler, G., & Ditschuneit, H. H. (2002). In vivo α1-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. Journal of Pharmacology and Experimental Therapeutics, 301(1), 229-233.
    3. Fontana, E., Morin, N., Prévot, D., & Carpéné, C. (2000). Effects of octopamine on lipolysis, glucose transport and amine oxidation in mammalian fat cells. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 125(1), 33-44.
    4. Marti, L., Morin, N., Enrique-Tarancon, G., Prevot, D., Lafontan, M., Testar, X., ... & Carpéné, C. (1998). Tyramine and vanadate synergistically stimulate glucose transport in rat adipocytes by amine oxidase-dependent generation of hydrogen peroxide. Journal of Pharmacology and Experimental Therapeutics, 285(1), 342-349.

    L-Theanine

    1. Park, S. K., Jung, I. C., Lee, W. K., Lee, Y. S., Park, H. K., Go, H. J., ... & Rho, S. S. (2011). A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. Journal of medicinal food, 14(4), 334-343.
    2. Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience, 11(4), 193-198.
    3. Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional neuroscience, 13(6), 283-290.

    Hordenine HCl

    1. Barwell, C. J., Basma, A. N., Lafi, M. A. K., & Leake, L. D. (1989). Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. Journal of pharmacy and pharmacology, 41(6), 421-423.
    2. Hapke, HJ, Strathmann, W. (1995). Pharmacological effects of Hordenine. Dtsch Tierarztl Wochenschr. 1995 Jun;102(6):228-32.
    3. Frank, M., Weckman, T. J., Wood, T., Woods, W. E., TAI, C. L., CHANG, S. L., … & Tobin, T. (1990). Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse. Equine veterinary journal, 22(6), 437-441.

    Rauwolfia

    1. Bemis, D. L., Capodice, J. L., Gorroochurn, P., Katz, A. E., & Buttyan, R. (2006). Anti-prostate cancer activity of a β-carboline alkaloid enriched extract from Rauwolfia vomitoria. International journal of oncology, 29(5), 1065-1073.
    2. Campbell, J. I., Mortensen, A., & Mølgaard, P. (2006). Tissue lipid lowering-effect of a traditional Nigerian anti-diabetic infusion of Rauwolfia vomitoria foilage and Citrus aurantium fruit. Journal of ethnopharmacology, 104(3), 379-386.
    3. Bisong, S. A., Brown, R., & Osim, E. E. (2010). Comparative effects of Rauwolfia vomitoria and chlorpromazine on locomotor behaviour and anxiety in mice. Journal of ethnopharmacology, 132(1), 334-339.
    4. Yu, J., Ma, Y., Drisko, J., & Chen, Q. (2013). Antitumor activities of Rauwolfia vomitoria extract and potentiation of carboplatin effects against ovarian cancer. Current Therapeutic Research, 75, 8-14.